'Gene Targeting in mice' , Trio shares Nobel 2007

Two Americans and a Briton won the 2007 Nobel for Medicine & Physiology for their work on 'Gene targeting in mice'.

Mario R. Capecchi (an Italian by birth), an American citizen from University of Utah, Sir Martin J. Evans from Cardiff (Knighted in 2004) and Oliver Smithies from University of North Carolina shared the prize for their discoveries of "principles for introducing specific gene modifications in mice by the use of embryonic stem cells".

Their discoveries led to the creation of an immensely powerful technology referred to as gene targeting in mice. It is now being applied to virtually all areas of biomedicine – from basic research to the development of new therapies. Their studies are the basis for the development of 'knockout mice', which have played a significant role in several discoveries in recent years.

press release: The Nobel Prize in Physiology or Medicine 2007

Read this interesting article from Nature 2004 on Mario Capecchi : From rags to research